Copine 9 is a 503 amino acid member of the copine family of evolutionarily conserved, soluble, calcium-dependent, membrane-binding proteins. Members of the copine family are involved in signal transduction and membrane trafficking. Arabidopsis thaliana mutants lacking copine proteins exhibit reduced cell number and smaller cell size, effects which may be due to a defect in vesicle fusion or transport. Copine 9 contains two N-terminal C2 domains and one SLCterminal VWFA (von Willebrand factor A) domain, which is also referred to as the A domain or the core domain. As is characteristic of the copine family, copine 9 functions in membrane trafficking and is capable of binding phospholipids in a calcium-dependent manner.
Function:
The exact functions of CPNE9 remain unknown but it may function in membrane trafficking. CPNE9 exhibits calcium-dependent phospholipid binding properties.
Similarity:
Belongs to the copine family.
Contains 2 C2 domains.
Contains 1 VWFA domain.
SWISS:
Q8IYJ1
Gene ID:
151835
Database links:
Entrez Gene: 151835 Human
Entrez Gene: 785580 Cow
Entrez Gene: 211232 Mouse
Entrez Gene: 297516 Rat
SwissProt: Q8IYJ1 Human
SwissProt: Q1RLL3 Mouse
SwissProt: Q5BJS7 Rat
Unigene: 121335 Human
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