Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 [PubMed 7590244]).[supplied by OMIM, Mar 2008]
Function:
CPSF1 (Cleavage and polyadenylation specificity factor subunit 1) is a component of the cleavage and polyadenylation specificity factor (CPSF) complex. It plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction.
Subcellular Location:
Nucleus, nucleoplasm.
Post-translational modifications:
The N-terminus is blocked.
Similarity:
Belongs to the CPSF1 family.
SWISS:
Q10570
Gene ID:
29894
Database links:
Entrez Gene: 29894 Human
Entrez Gene: 94230 Mouse
Entrez Gene: 366952 Rat
Omim: 606027 Human
SwissProt: Q10570 Human
SwissProt: Q9EPU4 Mouse
SwissProt: B5DEL2 Rat
Unigene: 49642 Human
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