cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. [provided by RefSeq, Jul 2008]
Function:
CREBL2 is frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene.
Subunit:
Interacts with CREB1; regulates CREB1 phosphorylation, stability and transcriptional activity (By similarity).
Subcellular Location:
Nuclear
Post-translational modifications:
Phosphorylated by AMPK.
Similarity:
Belongs to the bZIP family. ATF subfamily.
Contains 1 bZIP (basic-leucine zipper) domain.
SWISS:
Q70SY1
Gene ID:
1389
Database links:
Entrez Gene: 1389 Human
Entrez Gene: 537195 Cow
Entrez Gene: 232430 Mouse
Entrez Gene: 362453 Rat
Entrez Gene: 100038265 Xenopus tropicalis
Omim: 603476 Human
SwissProt: Q0VD32 Cow
SwissProt: O60519 Human
SwissProt: Q32M00 Mouse
SwissProt: Q5BJU6 Rat
SwissProt: A4IGK3 Xenopus tropicalis
Unigene: 591156 Human
Unigene: 267010 Mouse
Unigene: 107553 Rat
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