The protein encoded by this gene is found exclusively in the mitochondrion, where it catalyzes the transfer of a malonyl group from malonyl-CoA to the mitochondrial acyl carrier protein. The encoded protein may be part of a fatty acid synthase complex that is more like the type II prokaryotic and plastid complexes rather than the type I human cytosolic complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2012]
Function:
Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondrias.
Subcellular Location:
Mitochondrion.
Similarity:
Belongs to the type II malonyltransferase family.
SWISS:
Q8IVS2
Gene ID:
27349
Database links:
Entrez Gene: 27349 Human
Omim: 614479 Human
SwissProt: Q8IVS2 Human
Unigene: 349111 Human
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