The uronate cycle functions as an alternative glucose metabolic pathway, accounting for about 5% of daily glucose catabolism. The product of this gene catalyzes the dehydrogenation of L-gulonate into dehydro-L-gulonate in the uronate cycle. The enzyme requires NAD(H) as a coenzyme, and is inhibited by inorganic phosphate. A similar gene in the rabbit is thought to serve a structural role in the lens of the eye. [provided by RefSeq, Jul 2008]
Function:
CRYL1 is involved in the uronate cycle which functions as an alternative glucose metabolic pathway, accounting for about 5% of daily glucose catabolism. CRYL1 catalyzes the dehydrogenation of L-gulonate into dehydro-L-gulonate. The enzyme requires NAD(H) as a coenzyme, and is inhibited by inorganic phosphate.
Subcellular Location:
Cytoplasmic
Tissue Specificity:
Widely expressed, with highest levels in liver and kidney.
Similarity:
Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
SWISS:
Q9Y2S2
Gene ID:
51084
Database links:
Entrez Gene: 51084 Human
Entrez Gene: 68631 Mouse
Omim: 609877 Human
SwissProt: Q9Y2S2 Human
SwissProt: Q99KP3 Mouse
Unigene: 370703 Human
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