Galectins are a family of soluble b-galactoside-binding animal lectins that modulate cell-to-cell adhesion and cell-to-extracellular matrix (ECM) interactions and also play a role in tumor progression, pre-mRNA splicing and apoptosis. The Galectin-related protein (GRP), also designated HSPC159, is a 172 amino acid protein that contains one galectin domain. However, HSPC159 does not appear to bind carbohydrates or lactose because the critical residues required for binding are not conserved. The gene encoding HSPC159 maps to human chromosome 2, which consists of 237 million bases and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2, including Harlequin icthyosis, sitosterolemia and Alstr鰉 syndrome.
Function:
Does not bind lactose, and may not bind carbohydrates.
Subunit:
Monomer (Probable).
Similarity:
Contains 1 galectin domain.
SWISS:
Q3ZCW2
Gene ID:
29094
Database links:
Entrez Gene: 470387 Chimpanzee
Entrez Gene: 516629 Cow
Entrez Gene: 101141454 Gorilla
Entrez Gene: 29094 Human
Entrez Gene: 216551 Mouse
Entrez Gene: 72983 Rat
SwissProt: Q3ZCW2 Human
SwissProt: Q8VED9 Mouse
SwissProt: Q5R5K6 Orangutan
Unigene: 372208 Human
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