DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. [provided by RefSeq, Jul 2008]
Function:
ATP-dependent RNA helicase.
Tissue Specificity:
Ubiquitous. Most abundant in heart and brain, but with lowest levels in thymus and small intestine.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase SLCterminal domain.
SWISS:
Q9GZR7
Gene ID:
57062
Database links:
Entrez Gene: 57062 Human
Entrez Gene: 27225 Mouse
Omim: 606181 Human
SwissProt: Q9GZR7 Human
SwissProt: Q9ESV0 Mouse
Unigene: 510328 Human
Unigene: 3935 Mouse
Unigene: 475067 Mouse
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