This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Subcellular Location:
Nucleus; nucleolus.
Similarity:
Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase SLCterminal domain.
SWISS:
Q9H0S4
Gene ID:
51202
Database links:
Entrez Gene: 51202 Human
Entrez Gene: 67755 Mouse
Entrez Gene: 297685 Rat
SwissProt: Q9H0S4 Human
SwissProt: Q9CWX9 Mouse
Unigene: 719938 Human
Unigene: 166524 Mouse
Unigene: 73790 Rat
|
|
