DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp, are putative RNA helicases implicated in several cellular processes involving modifications of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family may be involved in embryogenesis, spermatogenesis, and cellular growth and division. DEAD box protein 52 (DDX52) is a 599 amino acid protein belonging to the DEAD box helicase family. Localized to the nucleus, DDX52 is phosphorylated by ATM or ATR upon DNA damage. DDX52 contains one helicase ATP-binding domain and one helicase SLCterminal domain
Subcellular Location:
Nucleus > nucleolus.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase SLCterminal domain.
SWISS:
Q9Y2R4
Gene ID:
11056
Database links:
Entrez Gene: 11056 Human
Entrez Gene: 78394 Mouse
Entrez Gene: 85432 Rat
SwissProt: A5D7C1 Cow
SwissProt: Q9Y2R4 Human
SwissProt: Q8K301 Mouse
SwissProt: Q99PT0 Rat
Unigene: 51117 Cow
Unigene: 590937 Human
Unigene: 280544 Mouse
Unigene: 18605 Rat
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