This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2012]
Function:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis and cellular growth and division. In the process of mRNA degradation, DDX6 may play a role in mRNA decapping. It forms a complex with DCP1A, DCP2, EDC3 and EDC4/HEDLS.
Subcellular Location:
Cytoplasm; P-body. Note: Processing bodies (PB).
SWISS:
P26196
Gene ID:
1656
Database links:
Entrez Gene: 1656 Human
Entrez Gene: 1649 Mouse
Entrez Gene: 500988 Rat
Omim: 600326 Human
SwissProt: P26196 Human
SwissProt: P54823 Mouse
Unigene: 408461 Human
Unigene: 267061 Mouse
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