Beta-defensins are small cationic peptides with broad-spectrum antimicrobial activity against a variety of enveloped viruses, fungi and bacteria. Produced in mucosal epithelia and neutrophils of several species, Beta-defensins are developmentally regulated. The family of Beta-defensin proteins share a common defensin-motif that is characterized by multiple cysteine residues and a highly conserved tertiary structure. Besides playing a significant role in host immune defense, many Beta-defensins also are involved in sperm maturation and capacitation. Beta-defensin 110 is a 67 amino acid secreted protein that has antibacterial activity. There are two isoforms of Beta-defensin 110 that exist as a result of alternative splicing events.
Function:
DEFB110 belongs to the beta-defensin family. It has antibacterial activity. There are two named isoforms produced by alternative splicing.
Subcellular Location:
Secreted
SWISS:
Q30KQ9
Gene ID:
245913
Database links:
Entrez Gene: 245913 Human
SwissProt: Q30KQ9 Human
Unigene: 571093 Human
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