Beta-defensins are small cationic peptides with broad-spectrum antimicrobial activity against a variety of enveloped viruses, fungi and bacteria. Produced in mucosal epithelia and neutrophils of several species, Beta-defensins are developmentally regulated. The family of Beta-defensin proteins share a common defensin-motif that is characterized by multiple cysteine residues and a highly conserved tertiary structure. Besides playing a significant role in host immune defense, many Beta-defensins also are involved in sperm maturation and capacitation. Beta-defensin 114 is a 69 amino acid secreted protein that has antibacterial activity.
Subcellular Location:
Secreted
SWISS:
Q30KQ6
Gene ID:
245928
Database links:
Entrez Gene: 245928 Human
Omim: 615243 Human
SwissProt: Q30KQ6 Human
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