Rabbit Anti-DENND1C antibody

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Connecdenn 3; DEN1C_HUMAN; DENN domain-containing protein 1C; Dennd1c; FAM31C; FLJ22757; Protein FAM31C.

Cat:

SL14270R

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human DENND1C:401-500/801

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1C, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]

Function:
Guanine nucleotide exchange factor (GEF) for RAB35

Subunit:
Exhibits low nucleotide-independent RAB35-binding activity. Interacts with clathrin heavy chain/CLTC and with AP2A2, but not with AP2B1.

Subcellular Location:
Cytoplasm; cytosol. Cytoplasmic vesicle; clathrin-coated vesicle.

Similarity:
Contains 1 dDENN domain.
Contains 1 DENN domain.
Contains 1 uDENN domain

SWISS:
Q8IV53

Gene ID:
79958

Database links:

Entrez Gene: 79958 Human

Omim: 613634 Human

SwissProt: Q8IV53 Human

Unigene: 236449 Human

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