Rabbit Anti-DENND4A antibody

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C-myc promoter-binding protein; DENN domain-containing protein 4A; DENN/MADD domain containing 4A; DENND4A; FLJ33949; IRLB; KIAA0476; MYCPBP; MYCPP_HUMAN.

Cat:

SL14272R

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Cow,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human DENND4A:1751-1863/1863

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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Encoding more than 700 genes, chromosome 15 is made up of approximately 106 million base pairs and is about 3% of the human genome. Angelman and Prader-Willi syndromes are associated with loss of function or deletion of genes in the 15q11-q13 region. In the case of Angelman syndrome, this loss is due to inactivity of the maternal 15q11-q13 encoded UBE3A gene in the brain by either chromosomal deletion or mutation. In cases of Prader-Willi syndrome, there is a partial or complete deletion of this region from the paternal copy of chromosome 15. Tay-Sachs disease is a lethal disorder associated with mutations of the HEXA gene, which is encoded by chromosome 15. Marfan syndrome is associated with chromosome 15 through the FBN1 gene.

Function:
Binds to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter.

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed ubiquitously. Highest expression in bone marrow, medium in peripheral blood lymphocytes and lowest in spleen. In brain, breast, and prostate, higher expression was seen in normal cells than in tumor cells. Expression is regulated in a growth- and cell cycle-dependent manner.

Similarity:
Contains 1 dDENN domain.
Contains 1 DENN domain.
Contains 1 MABP domain.
Contains 2 PPR (pentatricopeptide) repeats. Contains 1 uDENN domain.

SWISS:
Q7Z401

Gene ID:
10260

Database links:

Entrez Gene: 10260 Human

Omim: 600382 Human

SwissProt: Q7Z401 Human

Unigene: 654567 Human

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