Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasis of the ER. DERL2 is involved in the degradation of misfolded glycoproteins in the ER (Oda et al., 2006 [PubMed 16449189]).[supplied by OMIM, Mar 2008]
Function:
DERL2 (Derlin 2) may be involved in the degradation process of specific misfolded endoplasmic reticulum (ER) luminal proteins. Its precise role is however unclear. In contrast to DER1, it is not involved in the degradation of MHC class I heavy chains in cas of infection by the cytomegalovirus. DERL2 may play a role in cell proliferation.
Subcellular Location:
Endoplasmic reticulum; Multi-pass membrane protein.
Similarity:
Belongs to the derlin family.
SWISS:
Q9GZP9
Gene ID:
51009
Database links:
Entrez Gene: 51009 Human
Entrez Gene: 116891 Mouse
Omim: 610304 Human
SwissProt: Q9GZP9 Human
SwissProt: Q8BNI4 Mouse
Unigene: 286131 Human
Unigene: 28131 Mouse
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