Rabbit Anti-GSDMD antibody | Sunlong Medical

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DF 5L; DF5L; DFNA 5L; DFNA5L; FKSG 10; FKSG10; FLJ12150; Gasdermin D; Gasdermin domain containing 1; Gasdermin domain containing protein 1; Gasdermin domain-containing protein 1; Gasdermin-D; GasderminD; GSDMD_HUMAN; GSDMDC 1; GSDMDC1; Gas

Cat:

SL14287R

Species Reactivity：

Human,(predicted: Mouse,Rat,)

Immunogen：

KLH conjugated synthetic peptide derived from human GSDMD:31-150/484

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Product Overview：

Sample: Lane 1: Human Huvec cell lysates Lane 2: Human A431 cell lysates Lane 3: Human Hela cell lysates Primary: Anti-GSDMD (SL14287R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 53 kDaObserved band size: 59 kDa

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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Gasdermin D is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. Gasdermin D has been suggested to act as a tumor suppressor. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]

Function:
Belongs to the gasdermin family.

Similarity:
Belongs to the gasdermin family.

SWISS:
P57764

Gene ID:
79792

Database links:

Entrez Gene: 79792 Human

SwissProt: P57764 Human

Unigene: 118983 Human

Picture

Sample:
Lane 1: Human Huvec cell lysates
Lane 2: Human A431 cell lysates
Lane 3: Human Hela cell lysates
Primary: Anti-GSDMD (SL14287R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 53 kDa
Observed band size: 59 kDa

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Specific References (16) | SL14287R has been referenced in 16 publications.

[IF=3.258] Renhe Wang. et al. Identification of MicroRNA-92a-3p as an Essential Regulator of Tubular Epithelial Cell Pyroptosis by Targeting Nrf1 via HO-1. Front Genet. 2020; 11: 616947 WB,IHC ; Mouse.

PubMed:33505436

[IF=3.886] Zhaochun Liu. et al. Melatonin regulates trophoblast pyroptosis, invasion and migration in preeclampsia by inhibiting HtrA1 transcription through the microRNA-520c-3p/SETD7 axis. 2022 Feb 08 IHC ; Human.

PubMed:35137483

[IF=4.379] Li, Zhifeng. et al. Activation of the NLRP3 inflammasome and elevation of interleukin-1β secretion in infection by sever fever with thrombocytopenia syndrome virus. Sci Rep-Uk. 2022 Feb;12(1):1-13 WB ; Human.

PubMed:10.1038/s41598-022-06229-0

[IF=8.469] Meng, Liping. et al. METTL14 suppresses pyroptosis and diabetic cardiomyopathy by downregulating TINCR lncRNA. Cell Death Dis. 2022 Jan;13(1):1-13 WB,IHC ; Rat.

PubMed:35013106

[IF=3.418] Chunping Zhu. et al. Silencing lncRNA GAS5 alleviates apoptosis and fibrosis in diabetic cardiomyopathy by targeting miR-26a/b-5p. 2021 Jun 06 WB ; Mouse.

PubMed:34091757

[IF=3.038] Haixia Gong. et al. Downregulation of HOTAIR reduces neuronal pyroptosis by targeting miR-455-3p/NLRP1 axis in propofol-treated neurons in vitro. 2021 Feb 03 WB ; Rat.

PubMed:33534059

[IF=5.638] Yang F et al. Silencing long non-coding RNA Kcnq1ot1 alleviates pyroptosis and fibrosis in diabetic cardiomyopathy .(2018) Cell Death Dis.9(10):1000. WB,IHC ; Mouse.

PubMed:30250027

[IF=2.705] Yang L et al. High glucose inhibits proliferation and differentiation of osteoblast in alveolar bone by inducing pyroptosis. Biochem Biophys Res Commun. 2019 Nov 25. pii: S0006-291X(19)32206-5. WB&ICF&IHSLCP ; Mouse.

PubMed:3356258

[IF=2.945] Liu, Xin. et al. Dexmedetomidine inhibits endoplasmic reticulum stress to suppress pyroptosis of hypoxia/reoxygenation-induced intestinal epithelial cells via activating the SIRT1 expression. 2021 Sep 29 IF ; rat.

PubMed:34586578

[IF=4.932] Jindan He. et al. JNK inhibition alleviates delayed neurocognitive recovery after surgery by limiting microglia pyroptosis. Int Immunopharmacol. 2021 Oct;99:107962 WB,IF ; Mouse.

PubMed:34298396

[IF=3.943] Xiuhong Wang. et al. Protective effect of combination of anakinra and MCC950 against acute lung injury is achieved through suppression of the NF-κB-mediated-MAPK and NLRP3-caspase pathways. Int Immunopharmacol. 2021 Aug;97:107506 WB ; Mouse.

PubMed:34022766

[IF=4.858] Kun Hao. et al. Targeting BRD4 prevents acute gouty arthritis by regulating pyroptosis. Int J Biol Sci. 2020; 16(16): 3163–3173 WB ; Rat, Human.

PubMed:33162822

[IF=3.367] Chengcheng Xiao. et al. Tisp40 Induces Tubular Epithelial Cell GSDMD-Mediated Pyroptosis in Renal Ischemia-Reperfusion Injury via NF-κB Signaling. Front Physiol. 2020; 11: 906 WB,IF ; Mouse.

PubMed:32903383

[IF=5.055] Meng L et al. Doxorubicin induces cardiomyocyte pyroptosis via the TINCR-mediated posttranscriptional stabilization of NLR family pyrin domain containing 3. J Mol Cell Cardiol. 2019 Aug 21. pii: S0022-2828(19)30170-1. WB ; Rat.

PubMed:31445005

[IF=4.057] Yang F et al. Metformin Inhibits the NLRP3 Inflammasome via AMPK/mTOR-dependent Effects in Diabetic Cardiomyopathy. Int J Biol Sci 2019; 15(5):1010-1019. IF ; Mouse.

PubMed:10.7150/ijbs.29136

[IF=3.61] Yue E et al. Anthocyanin is Involved in the Activation of Pyroptosis in Oral Squamous Cell Carcinoma.(2018) Phytomedicine. IF ; Human.

PubMed:doi:10.1016/j.phymed.2018.09.223