This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Function:
May function as signaling molecule.
Isoform 2 may be involved in cell growth and tumorigenesis. Involved in clathrin-dependent endocytosis.
Subcellular Location:
Cytoplasm and Membrane.
Tissue Specificity:
Isoform 2 is ubiquitously expressed also in tumor tissues. Isoform 1 is expressed in ovary, spleen and some tumor-derived cells.
Post-translational modifications:
Isoform 1 H domain is phosphorylated.
Similarity:
Belongs to the eukaryotic diacylglycerol kinase family.
Contains 1 DAGKc domain.
Contains 1 PH domain.
Contains 2 phorbol-ester/DAG-type zinc fingers.
Contains 1 SAM (sterile alpha motif) domain.
SWISS:
Q16760
Gene ID:
8527
Database links:
Entrez Gene: 8527 Human
Omim: 601826 Human
SwissProt: Q16760 Human
Unigene: 471675 Human
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