DDX16 is a 1,041 amino acid protein that contains one helicase ATP-binding domain and one helicase SLCterminal domain. One of several members of the DEAD-box protein family, DDX16 localizes to the nucleus and is thought to function as an RNA helicase that is involved in pre-mRNA splicing events, playing an important role in cell cycle progression. The gene encoding DDX16 is located on a region of chromosome 6 that is associated with a variety of diseases, including malignancies and genetic mutations, suggesting a possible role for DDX16 in the pathogenesis of certain disorders.
Function:
Probable ATP-binding RNA helicase involved in pre-mRNA splicing.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the DEAD box helicase family. DEAH subfamily. DDX16/PRP8 sub-subfamily.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase SLCterminal domain.
SWISS:
O60231
Gene ID:
8449
Database links:
Entrez Gene: 8449 Human
Entrez Gene: 100719266 Human
Entrez Gene: 501285 Cow
Entrez Gene: 713836 Human
Entrez Gene: 69192 Mouse
Entrez Gene: 100144456 Pig
Entrez Gene: 294232 Rat
Entrez Gene: 336645 Zebrafish
Omim: 603405 Human
SwissProt: O60231 Human
SwissProt: Q767K6 Pig
Unigene: 485060 Human
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