DHX58, is a 678 amino acid protein belonging to the helicase family. LGP2 acts as a negative regulator of host innate immune defense against viruses by binding dsRNA produced during viral replication. The repressor domain of LGP2 binds to RIG-I, a signaling protein involved in host defenses against hepatitis C virus (HCV). By preventing RIG-I multimerization, LGP2 negatively regulates RIG-I-mediated signaling. Localized to the cytoplasm, LGP2 contains one helicase ATP-binding domain and one helicase SLCterminal domain.
Function:
Participates in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade which results in the induction and expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). The RNA helicase domain may recognize and structurally modify viral RNA to facilitate detection by DDX58/RIG-I or by IFIH1/MDA5 whose affinity for dsRNA is lower.
Subcellular Location:
Cytoplasm.
Similarity:
Belongs to the helicase family.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase SLCterminal domain.
SWISS:
Q96C10
Gene ID:
79132
Database links:
Entrez Gene: 79132 Human
Entrez Gene: 80861 Mouse
Entrez Gene: 303538 Rat
Omim: 608588 Human
SwissProt: Q96C10 Human
SwissProt: Q99J87 Mouse
Unigene: 55918 Human
Unigene: 271830 Mouse
Unigene: 105654 Rat
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