The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012]
Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity.
Subcellular Location:
Microsome. Mitochondrion outer membrane. Endoplasmic reticulum membrane.
Tissue Specificity:
Highly expressed in liver.
Post-translational modifications:
Peroxynitrite induces nitration at Tyr-93 which activates the enzyme.
Similarity:
Belongs to the MAPEG family.
SWISS:
P10620
Gene ID:
4257
Database links:
Entrez Gene: 4257 Human
Entrez Gene: 56615 Mouse
Entrez Gene: 171341 Rat
Omim: 138330 Human
SwissProt: P10620 Human
SwissProt: Q91VS7 Mouse
SwissProt: P08011 Rat
Unigene: 389700 Human
Unigene: 14796 Mouse
Unigene: 2580 Rat
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