This gene encodes a subunit of the integrator complex. The integrator complex associates with the SLCterminal domain of RNA polymerase II and mediates 3'-end processing of the small nuclear RNAs U1 and U2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Function:
Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the SLCterminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Plays a role in DNA damage response (DDR) signaling during the S phase.
Subunit:
Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12. Interacts with NABP2.
Subcellular Location:
Nucleus. Chromosome. Localizes to sites of DNA damage in a H2AX-independent manner.
Similarity:
Belongs to the Integrator subunit 7 family.
SWISS:
Q9NVH2
Gene ID:
25896
Database links:
Entrez Gene: 25896 Human
Entrez Gene: 421374 Chicken
Omim: 611350 Human
SwissProt: Q5ZL91 Chicken
SwissProt: Q1RMS6 Cow
SwissProt: Q9NVH2 Human
Unigene: 369285 Human
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