This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. [provided by RefSeq, Jul 2008]
Function:
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed in cerebellum, T-cells, esophagus and lung.
Post-translational modifications:
Appears to be not glycosylated.
Can be proteolytically processed by a furin-like protease.
Similarity:
Belongs to the dickkopf family.
SWISS:
Q9UBT3
Gene ID:
27121
Database links:
Entrez Gene: 27121 Human
Entrez Gene: 234130 Mouse
Entrez Gene: 502097 Rat
GenBank: NP_055235.1 Human
Omim: 605417 Human
SwissProt: Q9UBT3 Human
SwissProt: Q8VEJ3 Mouse
Unigene: 159311 Human
Unigene: 157322 Mouse
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