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Rabbit Anti-phospho-DLC1 (Ser567) antibody
This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010]
Function:
Functions as a GTPase-activating protein specific for Rho and an activator of PLCD1 in vivo and induces morphological changes and detachment through cytoskeletal reorganization.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Highest level of expression in the spleen, with rather lower levels in prostate, testis, ovary, small intestine and colon, but none in the thymus.
Similarity:
Contains 1 Rho-GAP domain.
Contains 1 SAM (sterile alpha motif) domain.
Contains 1 START domain.
SWISS:
Q96QB1
Gene ID:
10395
Database links:
Entrez Gene: 10395 Human
Omim: 604258 Human
SwissProt: Q96QB1 Human
Unigene: 134296 Human
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