DMRTA2 is a 542 amino acid protein that localizes to the nucleus and contains one DM DNA-binding domain. Expressed testis, DMRTA2 is thought to be involved in sexual developmental processes during maturation. The gene encoding DMRTA2 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.
Function:
May be involved in sexual development.
Subcellular Location:
Nucleus.
Tissue Specificity:
Expressed in testis.
Similarity:
Belongs to the DMRT family.
Contains 1 DM DNA-binding domain.
SWISS:
Q96SC8
Gene ID:
63950
Database links:
Entrez Gene: 63950 Human
Entrez Gene: 242620 Mouse
Entrez Gene: 313471 Rat
SwissProt: Q5TFQ3 Human
SwissProt: Q96SC8 Human
SwissProt: A2A9A2 Mouse
Unigene: 334481 Human
Unigene: 32825 Mouse
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