Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. The axonemal dyneins, found in cilia and flagella, are components of the outer and inner dynein arms attached to the peripheral microtubule doublets. DNAH2 is an axonemal inner arm dynein heavy chain (Chapelin et al., 1997 [PubMed 9256245]).[supplied by OMIM, Mar 2008]
Function:
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly.
Subcellular Location:
Cytoplasm; cytoskeleton; cilium axoneme.
Tissue Specificity:
Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in lung.
Similarity:
Belongs to the dynein heavy chain family.
Contains 5 TPR repeats.
SWISS:
Q9P225
Gene ID:
146754
Database links:
Entrez Gene: 146754 Human
SwissProt: Q9P225 Human
Unigene: 367649 Human
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