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Rabbit Anti-DNAJC5B antibody
The DnaJ family, one of the largest of all the chaperone families, has evolved with diverse cellular localization and functions. The presence of the J domain defines a protein as a member of the DnaJ family. DnaJ heat-shock induced proteins are derived from the bacterium Escherichia coli and are under the control of the htpR regulatory protein. The DnaJ proteins play a critical role in the HSP 70 chaperone machine by interacting with HSP 70 to stimulate ATP hydrolysis. Members of this family contain cysteine-rich regions that are composed of zinc fingers that form a peptide-binding domain responsible for the chaperone function. They are important mediators of proteolysis and are involved in the regulation of protein degradation, exocytosis and endocytosis. DnaJC5B is a 199 amino acid protein that contains one J domain and plays an important role in exocytosis. DnaJC5B is expressed in testis where it is tightly bound to lipid membranes. The palmitoylation level of DnaJC5B is thought to correlate with its targeting to specific membranes.
Function:
DnaJ is a testis-specific heat shock protein and functions in association with DnaK(Hsp70). It is a molecular chaperone to facilitate protein folding. DnaJ plays a key role in the chaperone reaction by stimulating the ATPase activity and activating the substrate binding of Hsp70.
Subcellular Location:
Membrane; Lipid-anchor.
Tissue Specificity:
Testis specific.
Post-translational modifications:
Palmitoylated. Palmitoylation is not required for membrane association.
Similarity:
Contains 1 J domain.
SWISS:
Q9UF47
Gene ID:
85479
Database links:
Entrez Gene: 85479 Human
Entrez Gene: 66326 Mouse
GenBank: NM_033105 Human
SwissProt: Q9UF47 Human
SwissProt: Q9CQ94 Mouse
Unigene: 491885 Human
Unigene: 45615 Mouse
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