The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Function:
Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.
Subunit:
Interacts with TRAF1, TRAF2, TRAF3 and TRAF5.
Subcellular Location:
Cytoplasm and Cell membrane.
Post-translational modifications:
Phosphorylated on serine and tyrosine residues.
Similarity:
Contains 6 TNFR-Cys repeats.
SWISS:
P28908
Gene ID:
21941
Database links:
Entrez Gene: 943 Human
Entrez Gene: 21941 Mouse
Omim: 153243 Human
SwissProt: P28908 Human
SwissProt:
Q60846 Mouse
Unigene:
1314 Human
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