The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2012]
Function:
Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity.
Subcellular Location:
Apical cell membrane. Cell projection; microvillus membrane. Brush border membrane.
Similarity:
Belongs to the peptidase M19 family.
SWISS:
P16444
Gene ID:
360
Database links:
Entrez Gene: 360 Human
Omim: 179780 Human
SwissProt: P16444 Human
Unigene: 109 Human
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