Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a subunit of dolichyl-phosphate mannosyltransferase and acts as a stabilizer subunit of the dolichyl-phosphate mannosyltransferase complex. [provided by RefSeq, Jul 2008]
Function:
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. DPM3 is a subunit of dolichyl-phosphate mannosyltransferase and acts as a stabilizer subunit of the dolichyl-phosphate mannosyltransferase complex.
Subcellular Location:
Integral membrane protein. Endoplasmic reticulum.
Similarity:
Belongs to the DPM3 family.
SWISS:
Q9P2X0
Gene ID:
54344
Database links:
Entrez Gene: 54344 Human
Entrez Gene: 68563 Mouse
Entrez Gene: 502017 Rat
Omim: 605951 Human
SwissProt: Q9P2X0 Human
SwissProt: Q9D1Q4 Mouse
Unigene: 110477 Human
Unigene: 272927 Mouse
Unigene: 20619 Rat
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