Consisting of around 63 million bases with over 1,400 genes, chromosome 19 makes up over 2% of human genomic DNA. Chromosome 19 includes a diversity of interesting genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin superfamily members including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family, and Fc receptors. Key genes for eye color and hair color also map to chromosome 19. Peutz-Jeghers syndrome, spinocerebellar ataxia type 6, the stroke disorder CADASIL, hypercholesterolemia and insulin-dependent diabetes have been linked to chromosome 19. Translocations with chromosome 19 and chromosome 14 can be seen in some lymphoproliferative disorders and typically involve the proto-oncogene BCL3.
Subcellular Location:
Membrane.
Tissue Specificity:
Widely expressed.
Similarity:
Belongs to the dpy-19 family.
SWISS:
Q6ZPD9
Gene ID:
147991
Database links:
Entrez Gene: 147991 Human
Omim: 613894 Human
SwissProt: Q6ZPD9 Human
Unigene: 194392 Human
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