The region of chromosome 21 between genes CBR and ERG (CBR-ERG region), which spans 2.5 Mb on 21q22.2, has been defined by analysis of patients with partial trisomy 21. It contributes significantly to the pathogenesis of many characteristics of Down syndrome, including morphological features, hypotonia, and mental retardation. This gene is found in this region and multiple transcripts may exist. It is mainly expressed in the placenta. [provided by RefSeq, Jul 2008]
Tissue Specificity:
Mainly expressed in placenta.
SWISS:
P56555
Gene ID:
10281
Database links:
Entrez Gene: 10281 Human
SwissProt: P56555 Human
Unigene: 23251 Human
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