DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]
Function:
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Subunit:
Homodimer. May form a heterodimers with other members of the Deltex family. Interacts with NOTCH1 (By similarity).
Subcellular Location:
Cytoplasm.
Similarity:
Belongs to the Deltex family.
Contains 1 RING-type zinc finger.
SWISS:
Q8N9I9
Gene ID:
191283
Database links:
Entrez Gene: 191283 Human
Entrez Gene: 80904 Mouse
Omim: 613142 Human
SwissProt: Q8N9I9 Human
SwissProt: Q80V91 Mouse
Unigene: 32374 Human
Unigene: 271724 Mouse
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