Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as an ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4.
Subcellular Location:
Cytoplasm.
Similarity:
Belongs to the Deltex family.
Contains 1 RING-type zinc finger.
Contains 2 WWE domains.
SWISS:
Q9Y2E6
Gene ID:
23220
Database links:
Entrez Gene: 23220 Human
Entrez Gene: 207521 Mouse
SwissProt: Q9Y2E6 Human
SwissProt: Q6PDK8 Mouse
Unigene: 523696 Human
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