Control of cell proliferation by Polycomb group proteins (PcG) is an important facet of cellular homeostasis and its disruption can promote tumorigenesis. CBX7 is a novel PcG protein which is found to control the growth of normal cells. CBX7 is a gene that encodes a Polycomb protein, as shown by sequence homology, its interaction with Ring1 and its localization to nuclear Polycomb bodies. CBX7 extends the lifespan of a wide range of normal human cells and immortalizes mouse fibroblasts by downregulating expression of the Ink4a/Arf locus. CBX7 does not inter-function or colocalize with Bmi1, and both can exert their actions independently of each other as shown by reverse genetics. CBX7 was highly expressed in three different prostate cancer cell lines and present at elevated levels in normal prostate. (Gil et al., 2004).
Subcellular Location:
Nuclear
Similarity:
Contains 1 chromo domain.
SWISS:
O95931
Gene ID:
23492
Database links:
Entrez Gene: 23492 Human
Entrez Gene: 525770 Cow
Entrez Gene: 52609 Mouse
Entrez Gene: 362962 Rat
Omim: 608457 Human
SwissProt: O95931 Human
SwissProt: Q8VDS3 Mouse
SwissProt: P60889 Rat
Unigene: 356416 Human
Unigene: 12512 Rat
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