This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein; additional variants may exist but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Function:
May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions.
Tissue Specificity:
Retina, cerebrum, cerebellum, brain stem, spinal cord, testis, ovary and small intestine.
Similarity:
Belongs to the recoverin family.
Contains 4 EF-hand domains.
SWISS:
P61601
Gene ID:
83988
Database links:
Entrez Gene: 83988 Human
Entrez Gene: 281940 Cow
Entrez Gene: 52589 Mouse
Entrez Gene: 553106 Rat
Omim: 606722 Human
SwissProt: P61602 Cow
SwissProt: P61601 Human
SwissProt: Q91X97 Mouse
SwissProt: Q5PQN0 Rat
Unigene: 492427 Human
Unigene: 136132 Human
Unigene: 283370 Mouse
Unigene: 13744 Rat
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