This gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the D-loop of tRNA. The resulting modified bases confer enhanced regional flexibility to tRNA. The encoded protein may increase the rate of translation by inhibiting an interferon-induced protein kinase. This gene has been implicated in pulmonary carcinogenesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]
Function:
DUS2L is a dihydrouridine synthase that catalyzes the reduction of the 5,6-double bond of a uridine residue on the displacement loop of tRNA. The resultant modified base, 5,6-dihydrouridine, appears to increase the conformational flexibility and dynamic motion of tRNA.
Subcellular Location:
Cytoplasmic and Endoplasmic reticulum. Note=Mainly at the endoplasmic reticulum.
Similarity:
Belongs to the dus family. Dus2 subfamily.
Contains 1 DRBM (double-stranded RNA-binding) domain.
SWISS:
Q9NX74
Gene ID:
54920
Database links:
Entrez Gene: 54920 Human
Omim: 609707 Human
SwissProt: Q9NX74 Human
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