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Rabbit Anti-DUSP14 antibody
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP SLCterminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
Function:
Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases.
Similarity:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Contains 1 tyrosine-protein phosphatase domain.
SWISS:
O95147
Gene ID:
11072
Database links:
Entrez Gene: 11072 Human
Entrez Gene: 507294 Cow
Entrez Gene: 491131 Dog
Entrez Gene: 51285 Mouse
Entrez Gene: 72580 Rat
GenBank: BC000370 Human
Omim: 606618 Human
SwissProt: Q17QM8 Cow
SwissProt: O95147 Human
SwissProt: Q7TPY1 Mouse
SwissProt: Q9JLY7 Mouse
Unigene: 91448 Human
Unigene: 48885 Mouse
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