This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.[provided by RefSeq, May 2010]
Function:
Involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2.
Subcellular Location:
Cytoplasm. Nucleus. Cytoplasmic vesicle. After dissociation upon AGTR stimulation, re-associates with ARRB2 on endocytic vesicles.
Similarity:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Contains 1 rhodanese domain.
Contains 1 tyrosine-protein phosphatase domain.
SWISS:
Q9BY84
Gene ID:
80824
Database links:
Entrez Gene: 80824 Human
Entrez Gene: 431336 Chicken
Entrez Gene: 70686 Mouse
Omim: 607175 Human
SwissProt: Q9BY84 Human
Unigene: 536535 Human
|
|