The human genome contains hundreds of repeats of the 3.3-kb family in regions associated with heterochromatin. The DUX gene family, including DUX1, resides within these 3.3-kb repeated elements (Beckers et al., 2001 [PubMed 11245978]). See DUX4 (MIM 606009).[supplied by OMIM, Mar 2008]
Function:
Probable transcription activator. Binds the P5 DNA element sequence 5'-GATCTGAGTCTAATTGAGAATTACTGTASLC3'.
Subcellular Location:
Nucleus. Actively transported through the nuclear pore complex.
Tissue Specificity:
Expressed in rhabdomyosarcoma TE671 cells as well as in several other normal and cancer cells.
Similarity:
Belongs to the paired homeobox family.
Contains 2 homeobox DNA-binding domains.
SWISS:
O43812
Gene ID:
26584
Database links:
Entrez Gene: 26584 Human
Omim: 611441 Human
SwissProt: O43812 Human
Unigene: 274469 Human
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