This gene encodes a member of a family of guanosine triphosphate (GTP)-binding proteins that associate with microtubules and are involved in vesicular transport. The encoded protein functions in the development of megakaryocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Function:
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis.
Subcellular Location:
Cytoplasm. Cytoplasm > cytoskeleton. Microtubule-associated.
Similarity:
Belongs to the dynamin family.
Contains 1 GED domain.
Contains 1 PH domain.
SWISS:
Q9UQ16
Gene ID:
26052
Database links:
Entrez Gene: 26052 Human
Entrez Gene: 103967 Mouse
Entrez Gene: 171574 Rat
Omim: 611445 Human
SwissProt: Q9UQ16 Human
SwissProt: Q8BZ98 Mouse
SwissProt: Q08877 Rat
Unigene: 654775 Human
Unigene: 441620 Mouse
Unigene: 11191 Rat
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