Rabbit Anti-DYNLT3 antibody

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2310075M16Rik; AU042796; DYLT3_HUMAN; Dynein light chain Tctex-type 3; DYNLT3; Protein 91/23; RP23-256J17.2; RP3; T-complex-associated testis-expressed 1-like; Tcte1l; TCTEX1L.

Cat:

SL14472R

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Horse,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human DYNLT3:31-116/116

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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This gene encodes a member of a subclass of dynein light chains. The encoded protein homodimerizes and forms the light chain component of the cytoplasmic dynein motor protein complex. This protein may be important for binding dynein to specific cargos including the spindle checkpoint protein BUB3. This protein may also function independently of dynein as a transcriptional modulator. Pseudogenes of this gene are found on chromosomes 2 and 20.[provided by RefSeq, Mar 2010]

Function:
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis.

Subcellular Location:
Nucleus. Cytoplasm; cytoskeleton. Chromosome; centromere; kinetochore. Colocalizes with BUB3 at kinetochores specifically during prometaphase.

Similarity:
Belongs to the dynein light chain Tctex-type family.

SWISS:
P5368

Gene ID:
6990

Database links:

Entrez Gene: 6990 Human

Entrez Gene: 363448 Rat

Omim: 300302 Human

SwissProt: P5368 Human

Unigene: 446392 Human

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