Home
>
Product
>
Antibody
>
Rabbit Anti-FXYD5/Dysadherin antibody
This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the SLCterminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J.
Function:
Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis.
Subcellular Location:
Membrane.
Post-translational modifications:
Glycosylated.
Similarity:
Belongs to the FXYD family.
SWISS:
Q96DB9
Gene ID:
53827
Database links:
Entrez Gene: 53827 Human
GenBank: NP_054883 Human
Omim: 606669 Human
SwissProt: Q96DB9 Human
Unigene: 333418 Human
|
|
