This gene encodes a phosphoprotein that interacts with several members of the E2F family of proteins. The protein localizes to the nucleus, and is present throughout the cell cycle except during mitosis. It functions to modulate E2F-regulated transcription and stimulate proliferation. [provided by RefSeq, Jul 2008]
Function:
May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression.
Subcellular Location:
Cytoplasm. Nucleus.
Tissue Specificity:
Ubiquitously expressed. Highest levels in heart, placenta, skeletal muscle and pancreas. Lower levels in brain, lung and kidney. In the brain, expressed in all regions with high levels in the cerebellum and cerebral cortex. Expressed in COS1 and transformed skin fibroblasts.
SWISS:
Q56P03
Gene ID:
55837
Database links:
Entrez Gene: 55837 Human
Entrez Gene: 66266 Mouse
Entrez Gene: 299043 Rat
Omim: 609486 Human
SwissProt: Q56P03 Human
SwissProt: Q5BU09 Mouse
Unigene: 433269 Human
Unigene: 15688 Mouse
Unigene: 55623 Rat
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