The replication and stable maintenance of latent Epstein-Barr virus DNA episomes in human cells requires only one viral protein, Epstein-Barr nuclear antigen 1 (EBNA1). EBNA1 binding protein 2, also designated p40/EBP2, is a nuclear protein required for the processing of the 27S pre-rRNA. EBP2 is highly conserved across species and is ubiquitously expressed in human tissues, especially myelogenous leukemia K-562. EBP2 specifically interacts with EBNA1, supporting the long-term maintenance of Epstein-Barr virus plasmids in human cells. The EBNA1-EBP2 complex is important for the stable segregation of Epstein-Barr virus episomes during cell division.
Function:
Required for the processing of the 27S pre-rRNA
Subcellular Location:
Nucleus > nucleolus.
Tissue Specificity:
Ubiquitous.
Similarity:
Belongs to the EBP2 family.
SWISS:
Q99848
Gene ID:
10969
Database links:
Entrez Gene: 10969 Human
Omim: 614443 Human
SwissProt: Q99848 Human
Unigene: 346868 Human
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