Epstein-Barr virus-induced gene 2 is a 357 amino acid multi pass membrane protein. It is expressed in B-lymphocytes and lymphoid tissues and may function in the modulation of the immune system. Out of the nine genes that are induced by the Epstein-Barr virus, Ebi2 exhibits the highest levels of up-regulation. Ebi2 is a G-protein coupled receptor that signals through the G-protein G錳. Ebi2 contains seven hydrophobic transmembrane regions and a putative N-linked glycosylation site at its extracellular N-terminus. Ebi2 is believed to be involved in regulating the effects of the Epstein-Barr virus on B-lymphocytes. In addition, Ebi2 may play a role mediating normal lymphocyte functions.
Function:
Orphan receptor that plays a central role during humoral immunity. Promotes activated B-cell localization in the outer follicle and interfollicular regions. Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity). Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha.
Subcellular Location:
Cell membrane.
Tissue Specificity:
Expressed abundantly in lymphoid tissues such as spleen and lymph node, and in B- and T-lymphocytes. Also highly expressed in lung, heart and gastrointestinal tract, and weakly expressed in the urogenital system and brain.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
SWISS:
P32249
Gene ID:
376
Database links:
Entrez Gene: 376 Human
Entrez Gene: 769212 Chicken
Entrez Gene: 540287 Cow
Entrez Gene: 100050745 Horse
Entrez Gene: 100388743 Marmoset (common)
Entrez Gene: 321019 Mouse
Entrez Gene: 679975 Rat
Omim: 605741 Human
SwissProt: Q1RMI1 Cow
SwissProt: P32249 Human
SwissProt: Q3U6B2 Mouse
SwissProt: D4A7K7 Rat
Unigene: 784 Human
Unigene: 265618 Mouse
Unigene: 179130 Rat
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