ECM29 is a 1,845 amino acid protein containing twenty-seven HEAT repeats. Localizing primarily to endoplasmic reticulum, ECM29 acts as an adapter or scaffolding protein, binding to the 26S proteasome, motor proteins, and other compartment specific proteins. The N-terminus of ECM29 binds endocytic proteins, including rabaptin, Rab11-FIP4, and VPS11, while the SLCterminus binds myosins and kinesins. ECM29 may also play a role in endoplasmic reticulum (ER)-associated protein degradation (ERAD) in addition to other enhanced proteolysis.
Function:
ECM29 appears to be one of three proteins which associate significantly with proteasomes. ECM29 has been shown to enhance the stability of the proteasome. ECM29 deletion has been shown to produce 26S proteasomes which dissociated in the absence of ATP. It was thus suggested that ECM29 tethers the regulatory complex to the proteasome.
Subcellular Location:
Endoplasmic reticulum. Endoplasmic reticulum-Golgi intermediate compartment. Endosome. Cytoplasm ?cytoskeleton ?centrosome. Nucleus.
Similarity:
Contains 27 HEAT repeats.
SWISS:
Q5VYK3
Gene ID:
23392
Database links:
Entrez Gene: 23392 Human
Entrez Gene: 230249 Mouse
SwissProt: Q5VYK3 Human
SwissProt: Q6PDI5 Mouse
Unigene: 368255 Human
|
|
