EFO1 is responsible for coupling cohesion and DNA replication processes thereby ensuring proper pairing of sister chromatids. EFO1 is phosphorylated during mitosis and this may act to regulate EFO1 activity. Due to alternative splicing events, three EFO1 isoforms exist.
Function:
Acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3.
Subcellular Location:
Nucleus. Chromosome. Nuclear at interphase, associated with chromosomes during mitosis.
Tissue Specificity:
Widely expressed. Expressed in heart, brain, liver, placenta, lung, kidney and pancreas. Highly expressed in muscle.
Post-translational modifications:
Phosphorylated during mitosis. Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the acetyltransferase family. GCN5 subfamily.
SWISS:
Q5FWF5
Gene ID:
114799
Database links:
Entrez Gene: 114799 Human
Entrez Gene: 77805 Mouse
Omim: 609674 Human
SwissProt: Q5FWF5 Human
SwissProt: Q69Z69 Mouse
Unigene: 464733 Human
Unigene: 210996 Mouse
Unigene: 450684 Mouse
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