This gene encodes a protein that may regulate endothelial cell differentiation, lipid metabolism, and hormone-induced cardiomyocyte hypertrophy. The encoded protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Function:
Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism.
Subcellular Location:
Cytoplasm. Nucleus. Also nuclear upon binding to NR5A1 and treatment of cells with TPA or forskolin.
Tissue Specificity:
Expressed in brain, liver, lung, kidney and heart (at protein level). Ubiquitously expressed. More abundant in heart, pancreas, liver, intestine and adipose tissues.
Post-translational modifications:
Phosphorylated (by PKA and PKC).
Similarity:
Contains 1 HTH cro/C1-type DNA-binding domain.
SWISS:
O60869
Gene ID:
8721
Database links:
Entrez Gene: 8721 Human
Entrez Gene: 417286 Chicken
Entrez Gene: 515380 Cow
Entrez Gene: 59022 Mouse
Entrez Gene: 296570 Rat
Omim: 605107 Human
SwissProt: Q3T0V7 Cow
SwissProt: O60869 Human
SwissProt: Q9JMG1 Mouse
SwissProt: P69736 Rat
Unigene: 174050 Human
Unigene: 29945 Mouse
Unigene: 17092 Rat
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