Rabbit Anti-EFCAB6 antibody

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DJBP; CAP binding protein complex interacting protein 1; DJ1 binding protein; DJBP; EFCB6_HUMAN; EF hand calcium binding domain 6; FLJ23588.

Cat:

SL14514R

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Cow,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human EFCAB6:1401-1501/1501

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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This gene encodes a protein which directly binds the oncogene DJ-1 and androgen receptor to form a ternary complex in cells. This binding protein recruits histone-deacetylase complexes in order to repress transcription activity of androgen receptor. This protein may also play a role in spermatogenesis and fertilization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Function:
Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ1 antagonizes this inhibition by abrogation of this complex. Six named isoforms produced by alternative splicing.

Subunit:
Binds PARK7. Part of a ternary complex containing PARK7, EFCAB6/DJBP and AR.

Subcellular Location:
Nucleus.

Tissue Specificity:
Specifically expressed in the testis.

Similarity:
Contains 17 EF-hand domains.

SWISS:
Q5THR3

Gene ID:
6960

Database links:

Entrez Gene: 6960 Human

SwissProt: Q5THR3 Human

Unigene: 658996 Human

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