This gene belongs to a highly conserved gene family encoding EPS15 homology (EH) domain-containing proteins. The protein-binding EH domain was first noted in EPS15, a substrate for the epidermal growth factor receptor. The EH domain has been shown to be an important motif in proteins involved in protein-protein interactions and in intracellular sorting. The protein encoded by this gene is thought to play a role in the endocytosis of IGF1 receptors. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]
Function:
Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes.
Subcellular Location:
Cell membrane. Early endosome membrane. Recycling endosome membrane. Associated with intracellular tubulovesicular structures.
Tissue Specificity:
Highly expressed in testis.
Similarity:
Contains 1 EF-hand domain.
Contains 1 EH domain.
SWISS:
Q9H4M9
Gene ID:
10938
Database links:
Entrez Gene: 10938 Human
Entrez Gene: 13660 Mouse
Entrez Gene: 293692 Rat
Omim: 605888 Human
SwissProt: Q9H4M9 Human
SwissProt: Q9WVK4 Mouse
SwissProt: Q641Z6 Rat
Unigene: 523774 Human
Unigene: 710868 Human
Unigene: 30169 Mouse
Unigene: 471458 Mouse
Unigene: 8141 Rat
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